About RxBiologics
The RxCelerate group of companies provides a platform for out-sourced drug discovery and development services and has a client base ranging from virtual biotech companies to some of the top 15 global pharmaceutical companies. We design and deliver complete drug development programmes from inception through to and including Phase II clinical studies. RxBiologics is a subsidiary of RxCelerate with a focus on delivery of biologics drug discovery. Our aim is to become the antibody drug developer of choice for the UK’s venture backed biotech start-ups and outsourced pharma projects.

RxBiologics has an excellent opportunity for an enthusiastic and motivated scientist to join our team and help deliver services and capabilities to support our growing client base. The position is based within the RxBiologics team, working at the Babraham Research Campus, a leading site within the Cambridge biotechnology hub.

The Role
The successful candidate will have a strong interest in biologics drug discovery. They will have an outstanding working knowledge of molecular biology techniques and antibody display approaches used in antibody projects. They will support the delivery of client and internal programmes by performing phage display selections, sequence analysis and characterisation of antibodies. In addition, they will scientifically lead client projects ensuring delivery of high-quality data within expected scope and timelines. This is a full-time, lab-based role and it is expected that the successful candidate will perform work independently to a high standard. They will have a proactive approach, be an exceptional team-worker and motivated to learn new skills and take on additional responsibilities.

Main Responsibilities
•\tLead phage display campaigns to isolate and optimise antibodies.
•\tPerform molecular biology to facilitate gene cloning and antibody library construction.
•\tAnalysis of DNA and antibody sequences to enable lead selection and decision making.
•\tDevelopment and running of plate-based immunoassays including ELISAs and TR-FRET assays for screening.
•\tProfiling of antibody lead panels for affinity, epitope, functional activity and biophysical properties.
•\tScientific leadership of client projects.
•\tProvision of cross-functional support for delivery of drug discovery campaigns.
•\tAnalysis and interpretation of experimental data.
•\tMaintenance of experimental records and delivery of high-quality reports.

Skills/Requirements
•\tPhD or equivalent experience within a relevant technical area and extensive biologics discovery knowledge ideally gained from working within the pharmaceutical/biotechnology industry.
•\tExperience in the design and execution of phage display campaigns for lead isolation and affinity maturation of antibodies to target proteins.
•\tProven molecular biology skills; working independently to perform PCR, cloning and library construction, DNA sequence analysis and QC.
•\tIn depth knowledge of antibody sequence analysis.
•\tPractical experience of running 96 and 384 well plate based assays to identify antibody leads
•\te.g., ELISA, homogeneous assays.
•\tUnderstanding and experience of performing assays used for the profiling of lead antibody panels such as SPR, BLI, biophysical characterisation.
•\tExperience of cell culture and running functional profiling assays is an advantage.
•\tAbility to independently interpret data, troubleshoot and set up new workflows.
•\tExcellent organisational skills with ability to prioritise multiple tasks and proven track record of delivering projects to timely completion.
•\tDemonstrated ability to work effectively in a team.
•\tProactive approach to resolving technical challenges.
•\tGood interpersonal, communication and presentation skills.
•\tDemonstrates our Company values of Agile and Collaborative, Courage and Innovation, Excellence, Vibrant and Compassionate.

RxBiologics offers a competitive salary with an annual bonus scheme and company benefit package.

When applying for this role, please include a cover letter outlining how you meet the competencies described above. Informal enquiries can be directed to this email address careers@rxcelerate.com.