Job Title: Vice President, Clinical Affairs

Location: London, UK (Hybrid – 2 days per week onsite)

Job Type: Permanent

About the Role

We are seeking a seasoned and strategically minded Vice President of Clinical Affairs to lead the global clinical development function for an innovative Class III cardiovascular medical device portfolio. This is a critical executive role, operating at both board and operational levels, responsible for shaping clinical strategy, advising senior leadership, and ensuring the successful design and execution of complex clinical programs—from first-in-human through pivotal trials.

This position requires a highly experienced clinical leader who can confidently navigate the nuances of early feasibility studies, first-in-human trials, and pivotal study design, particularly within cardiovascular and implantable device environments.

Key Responsibilities

• Define and lead global clinical strategy aligned with regulatory and commercial objectives
• Act as a trusted advisor to the Board and Executive Leadership Team on clinical development pathways, risk, and opportunity
• Design innovative and efficient clinical development plans, including feasibility, first-in-human, and pivotal trials
• Assess and advise on optimal geographies for early-stage trials (e.g., Netherlands, Australia), including regulatory, ethical, and operational considerations
• Evaluate opportunities to streamline development timelines, including combining or sequencing early-phase studies where appropriate
• Provide expert guidance on study design, endpoints, patient selection, and statistical methodologies for Class III cardiovascular devices
• Oversee clinical trial execution, ensuring quality, compliance, and timely delivery
• Collaborate closely with Regulatory Affairs to align clinical evidence generation with MDR, FDA, and global requirements
• Engage with investigators, key opinion leaders (KOLs), and clinical partners to build strong study networks
• Lead interactions with regulatory bodies and ethics committees as needed
• Build and lead a high-performing clinical affairs team and external partnerships (CROs, consultants)
• Oversee clinical budgets, timelines, and resource allocation

Required Experience & Qualifications

• Extensive experience in Clinical Affairs within the medical device industry, with a focus on Class III cardiovascular or implantable devices
• Proven track record designing and executing first-in-human, early feasibility, and pivotal clinical trials
• Deep understanding of global clinical and regulatory frameworks, including EU MDR and US FDA requirements
• Demonstrated experience advising executive leadership and Boards on clinical strategy and development pathways
• Strong expertise in trial design, including adaptive designs and efficient study sequencing
• Experience working with international trial sites, particularly in Europe and Australia
• Ability to critically assess and optimise clinical development order, timelines, and evidence generation strategies
• Strong leadership, communication, and stakeholder management skills

Desirable

• Experience in start-up or scale-up environments
• Familiarity with combining early-phase studies or innovative trial methodologies
• Strong network of cardiovascular investigators and clinical experts
• Advanced degree (MD, PhD, or equivalent) in a relevant discipline

What We Offer

• Competitive executive compensation and benefits package
• Opportunity to lead clinical strategy for groundbreaking cardiovascular technologies
• Direct influence at Board level and across global development strategy
• Collaborative, innovation-driven environment
• Hybrid working model with London office presence (2 days per week)

If you are a visionary clinical leader with deep expertise in cardiovascular medical devices and a passion for bringing transformative therapies to patients efficiently and safely, we would love to hear from you.