Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS's world‑first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future. Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK's position as the best place to discover, prove and benefit from genomic innovations. We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody. Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems. We're on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime - from birth to old age. Job Description We’re hiring a Senior Product Manager to take strategic ownership of live, national‑scale genomics products and shape the future of the Generation Study. What we're doing The Generation Study is one of Genomics England's most ambitious programmes – a national study exploring how whole genome sequencing can improve the diagnosis of rare genetic conditions in newborn babies and providing evidence to inform the government's future strategy on genomic newborn sequencing. We've built the products that make it work and they are running at scale. Now we need someone to own them through the next – and arguably the most strategically interesting – phase of the study. The Products

Generation Study Portal – the intake tool through which participants enter the study and which currently holds the contact, demographics and consent information. Bioinformatic Pipeline – the engine that processes whole genome sequencing data at scale and prioritises variants. Variant Review Tool – the interpretation product used by clinicians to review genomic findings and generate reports for the NHS consultants.

All three products are live and at a stable point in their lifecycle. Feature development is less intense now, focused mainly on iterative changes that are critical to the continued success of the mission. This role has an opportunity to spend some time looking ahead strategically and think carefully about what comes next. The Squad You’ll be the Product Lead for the NII (Newborns Intake and Interpretation) Squad – a newly merged team that previously operated as three separate squads. The squad is fresh, the ways of working are still being established, and you’ll be working alongside a new squad coach who will handle day‑to‑day squad operations. This is a moment of real transition, and the right person will find that energising rather than unsettling. What makes this role unusual The Generation Study is halfway through recruitment and will finish this early 2027 – what happens after that is genuinely open. It might mean evolving the products to support closedown of study processes followed by sunsetting and migrating their data capabilities into longer‑lived Genomics England infrastructure. It might mean a managed lessons‑learned process as the study concludes and understanding what components could transfer into a next phase. It might mean something more expansive: evolving these products into a new platform for APGP, supporting a reanalysis of samples against a childhood panel, or building remote consent capability for a new phase of the study. It could be elements of all of this. We don’t know yet. When we do know, it will need to happen quickly and to a high standard. We need someone who can hold the live products steady, build trust with a newly merged squad, and be ready to think and move strategically – in whichever direction the mission requires. You’ll need to draw on resources across Genomics England, spot and investigate parallels with other programmes, and work out the best path forward from first principles when the time comes. If that kind of strategic ambiguity sounds like an opportunity rather than a problem, you are the kind of person we are looking for. What you'll be doing

Holding strategic ownership of the GSP, bioinformatic pipeline and VRT – ensuring they run reliably and that any critical changes are well‑considered and well‑executed. Helping a newly merged squad find its feet – establishing shared ways of working alongside a new squad coach, and creating the conditions for the team to do its best work. Staying close to the study’s direction of travel, building relationships across Genomics England, and positioning the squad to move quickly when the path forward becomes clear. Thinking across possible futures – sunset, migration, evolution, new capability – and being ready to develop and execute a credible strategy for whichever materialises. Managing stakeholders with clarity and confidence, being transparent about priorities, trade‑offs, and uncertainty. Mentoring and supporting team members, and contributing to product management practice across Genomics England.

What we're looking for Essential

Experienced Senior Product Manager, comfortable owning complex products in live, production environments. Strategic thinker who can operate effectively under uncertainty and pivot when direction changes. Strong understanding of data products and backend systems – able to go deep with engineers when it matters. Excellent stakeholder management – able to hold credibility at senior levels while remaining genuinely collaborative. A natural connector – someone who seeks out parallels, draws on expertise from across an organisation, and builds the relationships needed to make things happen. Calm, grounded, and proactive – someone who figures things out rather than waiting to be told what to do. Experience leading and mentoring teams, and creating collaborative environments where people do their best work.

Preferred

Experience managing product close‑down, migration, or transition – including sunsetting products responsibly. Experience with complex data pipelines or bioinformatic / scientific software products. Scientific background – comfortable with biological or clinical language and engaging with genomics concepts.

Prior genomics experience is not required. The focus is on strategic product management capability and the confidence to operate well in ambiguity. Why this role The Generation Study is asking whether genomic sequencing could become a routine part of newborn care – catching rare conditions earlier and changing outcomes for families. The products you’ll own are what make that possible right now, at national scale. Qualifications You’ll have a demonstrable track record as a Senior Product Manager. While your qualifications provide a foundation, we’re particularly interested in the breadth and depth of your experience, as this gives a clearer picture of what you can bring to the role. Prior genomics experience is not required – the focus is on strategic product management capability and the confidence and experience to operate effectively in ambiguity. Additional Information Salary From: £86,100 Please note: This is a 1 Year FTC (Fixed Term Contract) Closing Date: Monday 13th April at 23:00 (UK time) Equal opportunities and our commitment to a diverse and inclusive workplace Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background. Genomics England's policies of non‑discrimination and equity will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part‑time or employed under a permanent or a fixed‑term contract or any other relevant factor. Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity. We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us. Culture We have four key behaviours that represent what we would like Genomics England to feel like and the culture we want to encourage, in order for us to achieve our mission. These behaviours help us all work well together, deliver on our outcomes, celebrate our successes and share feedback with each other. You can read about these and other aspects of our culture here Culture / Genomics England Blended working model Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However, this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to, however, some of our roles require full time on site attendance e.g., lab teams, reception team. Our teams and squads have, and will continue to reflect on what works best for them to work together successfully and have the freedom to design working patterns to suit, beyond the minimum. Our office locations are: Canary Wharf, Cambridge and Leeds. Onboarding background checks As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare. #J-18808-Ljbffr